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Charge Variant Analysis

Separation Science Charge Variant Analysis (CVA) offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for charge variant analysis.

Featured Educational Resources

Using the NISTmAb reference standard to demonstrate a simple approach to charge variant analysis

Application Article

The aim of this work was to demonstrate the effectiveness of a simple pH gradient/ion-exchange chromatography workflow approach to the characterization of charge variants in monoclonal antibodies using the NISTmAb reference standard as a model analyte. To show the assay is simple, reproducible, easily optimized, and resolves variants more effectively than previously published salt gradients.

Faster, Easier, and Better Biopharmaceutical Charge Variant Profiling

Technical Animation

Learn how patented pH gradient buffer kits enable you to easily produce linear pH gradients for fast and robust therapeutic protein separations.

Biopharma Applications Compendium

Application Articles

Are you looking for a comprehensive source of applications information for biopharmaceutical methods? If so, this biopharma applications compendium is what you need. Sign up for your free copy now...

Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate

Application Article

The aim of this study was to demonstrate the effectiveness of a simple pH gradient/ion-exchange chromatography workflow approach to the characterization of the different charge variants profiles of an innovator molecule (cetuximab) and a candidate biosimilar. To show the assay is simple, reproducible, easily optimized and resolves variants effectively.

Biopharmaceutical Application Notebook

Application Articles

A compilation of more than twenty application notes covering important aspects of biopharmaceutical analysis such as charge isoforms and determination of drug-to-antibody ratio (DAR) of ADCs. The last section of the notebook provides tips and tricks to improve chromatographic separation of biomolecules.

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